Organ Preservation and Resuscitation

Department: Surgery, UMCG

Supervisor: Leonie Venema MSc PhD-student and Yvonne de Vries, MD PhD-student

Organ transplantation is the best treatment for patients with end-stage organ failure. When transplanting an organ, a period of preservation is logistically inevitable due to transport of the organ from the donor to the recipient. At this time, the organs are outside of the human body and deprived of nutrients and oxygen. This is detrimental to the organ. For some organs this period of time is too damaging and the organ cannot recover from it, which will result in a failed transplantation.

With machine perfusion, the damage can be limited by mimicking the human body: supplying oxygen and nutrients via the blood vessels that are attached to a machine. In this workshop, we will provide you with the necessary background information of organ preservation (presentation). Furthermore, we will demonstrate machine perfusion with porcine organs in the surgical research laboratorium. In this laboratory, research was conducted that has lead to implementation of machine perfusion in the clinical setting today, in which the UMCG is a substantial player in the international field of transplantation.